Nitrogen oxide (NO) and creatine interact in skeletal muscle cells. So is supplement of creatine and NO helpfull?
Dear Peter, I hope can hel you,
The answer is: it depends on.. many factors, for it, I send you this articles.
Sestili, P., Barbieri, E., & Stocchi, V. (2016). Effects of creatine in skeletal muscle cells and in myoblasts differentiating under normal or oxidatively stressing conditions. Mini reviews in medicinal chemistry, 16(1), 4-11.
Gualano, B.; Artioli, G.G.; Poortmans, J.R.; Lancha Junior, A.H., Exploring the therapeutic role of creatine supplementation. Amino Acids, 2010, 38(1), 31-44.
Ingwall, J.S., Creatine and the control of muscle-specific protein synthesis in cardiac and skeletal muscle. Circ Res, 1976, 38(5 Suppl 1), I115-23
Mitchell, W. K., Phillips, B. E., Wilkinson, D. J., Williams, J. P., Rankin, D., Lund, J. N., ... & Atherton, P. J. (2017). Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men. Clinical Nutrition, 36(6), 1573-1579.
Hong, Y. H., Betik, A. C., & McConell, G. K. (2014). Role of nitric oxide in skeletal muscle glucose uptake during exercise. Experimental physiology, 99(12), 1569-1573.
Filippin, L. I., Moreira, A. J., Marroni, N. P., & Xavier, R. M. (2009). Nitric oxide and repair of skeletal muscle injury. Nitric Oxide, 21(3-4), 157-163.
Anderson, J. E. (2000). A role for nitric oxide in muscle repair: nitric oxide–mediated activation of muscle satellite cells. Molecular biology of the cell, 11(5), 1859-1874.
Best Regards
I have experiance with local stimulating of NO, in pain treatment. we can stimulate it with acupuncture.
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