Sorry for the cryptic first response--I was hurrying out to get my kids! :)
To my understanding, Stephanie is correct on both counts. Two major neurogenic niches have been shown to be significantly active in adults: one feeds the rostral migratory stream and helps you keep your smeller going, and the other feeds into the hippocampus. That said, I believe that much more evidence exists for the plasticity of the system, i.e. existing neurons taking over the function of lost ones, than for out-and-out replacement.
The PNS is a different story from the CNS. Rewiring can and does happen in periphery. This type of thing has not been shown convincingly in CNS, except with experimental manipulation of immune system, glia, chemokines, etc.
It's been thought for really long they were not but recent studies (well maybe it's been few years now) showed that there is stem cells in the adult brain who can proliferate to generate new neurons. I think regeneration is quite limited though. You should look on Pubmed for some specific papers about it.
Sorry for the cryptic first response--I was hurrying out to get my kids! :)
To my understanding, Stephanie is correct on both counts. Two major neurogenic niches have been shown to be significantly active in adults: one feeds the rostral migratory stream and helps you keep your smeller going, and the other feeds into the hippocampus. That said, I believe that much more evidence exists for the plasticity of the system, i.e. existing neurons taking over the function of lost ones, than for out-and-out replacement.
The PNS is a different story from the CNS. Rewiring can and does happen in periphery. This type of thing has not been shown convincingly in CNS, except with experimental manipulation of immune system, glia, chemokines, etc.
Stem cells is imp. To think about
regards
dr. Moahamme a.w.mohammed ali md.,ficms.,dm
Stem cell is very important and lot of research have been carried out on stem cell in medical sciences and biology. The application of stem cells in various fields like agriculture, for better yield, or the grafting of stem cell for treatment of heart disease or fixing bones. many a research is going on to facilitate mankind. stem cell is the basic unit that develop in to full fledged baby
Stem cells are indeed fascinating to me in their ability to summon the capabilities of mature cells of specific lineages before they themselves are committed to a fate decision. A fellow coworker in our lab, Dr. Lu, just published a fascinating story regarding the phagocytic properties of doublecortin+ neural progenitor cells in Nature Cell Biology. Check it out!
http://www.nature.com/ncb/journal/v13/n9/full/ncb2299.html
- Badges
- Science topic
- Similar topics
- Biological Science
- Neuroscience