I am sure it will be, let's say, at least challenging to found a startup company anywhere (and in any field). "Traditionally" the Stanford area (S.F./Bay area/Silicon Valley) appears to be the role model with many advantages if one could make it there, but how about, for example, Heidelberg/Germany? What could be the different challenges despite language (I am German, i.e. speak German, my english improved over the last 15 years after I left Stanford - and in my perception is OK, but is far from being perfect). So what else could be different?