Does anyone know a good mouse model of neonatal exposure to maternal obesity?
Michelle Baack
Kent,
It depends on the question you are asking. Our lab studies the effects of maternal high fat diet on DOHaD in offspring. Others use a Western diet (high fat and carbohydrates). There is the Agouti mouse model (from Duke) and a leptin knock out mouse (ob/ob) that is obese and develops Type 2 diabetes. Many things to consider in your study design - See Rebecca Simmons Review including PMID: 21110912 and others.
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