Hello,

As part of my research projection I am running DNA samples through the MinION and MinKnow software from Oxford Nanopore and I am torn between options. Part of my research is looking at methylation in DNA and there is a methylation basecalling option from MinKnow, but even after selection that option and looking at the results I cannot find the bases that are methylated. Reading on the community page most people seem to run the fas5 files through another software like Megaladon or NanoPolish but then that makes me curious: what is the difference then between the fast basecalling option and the methylation option if you have to run them through another software afterward anyway?