To design a device with a microarray for genotyping viral DNA in a blood sample.
The viral DNA sequence of the viral DNA which can be used for PCR-amplification has a length of 320 bp within 3 mutations in a distance of 50 bp. Every mutation stands for one viral genotype.
What are the physico-chemical suppositions of the device and the design of the device within the biofunctional surface and the way to diagnosis?
Thank you
Frederic Lepretre
Hi Isha
I suggest you to align the variants in the sequence and select probes, containing the variant but not the neighboring ones. to be faster, since they are 50 bp away from each other, the best way would be to choose your probes across each variant. it will therefore be a present/absent test.
fred
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