There is no known medication or therapeutic technique that is able to completely prevent malignancies, oral or otherwise. Anyone who claims that metformin completely prevents Breast cancer is either a misinformed medical lay person, or a quack practitioner.

The first line of diabetes medications has been shown to reduce the risk of breast cancer among its wide range of benefits including cognitive impairment (type 3 diabetes) and low risk of hypoglycemia.

We used metformin and glibenclamide as a standard drug to treat diabetes in our experimental model. Literature reports also show its beneficial effect in brest cancer as it consider antitumor agent. Here i am attaching a link of review to explain the exact story behind your question.. Good luck

https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0598-8

Your comments are very interesting

Type 2 Diabetes and Insulin resistance is associated with an increased risk of many cancers, including breast cancer

If insulin resistance is part of the main pathogenesis, then using a marker of insulin resistance [ eg HOMA-IR] could give one a risk predictor for these cancers as well as a means of monitoring response to cancer therapy combined with insulin sensitizing therapy

Has anyone done research on relating HOMA-IR to risk of these cancers? Is it a useful predictor of cancer?

Should we be considering insulin sensitizing therapy to one day becoming routine additions to patients with cancer and insulin resistance?

Thank you for your insightful views

Regards

YES, there is some research supporting this notion and i could not find anything contrasting that:

1-Article Impact of Diabetes, Insulin, and Metformin Use on the Outcom...

2-Article Metformin inhibits the development, and promotes the resensi...

3- Article Metformin inhibits stromal aromatase expression and tumor pr...

So data is emerging to support its use. i would appreciate if someone can share a contrasting evidence

Regards

This referenced schematic shows response of metformin in rats with and without breast cancer

Article Metformin as an energy restriction mimetic agent for breast ...

This schematic shows the mechanism of action of metformin in reducing downstream to pathways to reduce cancer treatment targets

Reference- http://clincancerres.aacrjournals.org/content/20/10/2508

This is fascinating

Huge clinical implications

Thank you

Please check

1. Lega IC, Fung K, Austin PC, Lipscombe LL. Metformin and breast cancer stage at diagnosis: a population-based study. Curr Oncol. 2017;24(2):e85-e91.

2. Laura Camacho, Atreyi Dasgupta, and Sao Jiralerspong. Metformin in breast cancer - an evolving mystery. Breast Cancer Research201517:88

3. Zi F, Zi H, Li Y, He J, Shi Q, Cai Z. Metformin and cancer: An existing drug for cancer prevention and therapy. Oncol Lett. 2017;15(1):683-690.

4. He H, Ke R, Lin H, Ying Y, Liu D, Luo Z. Metformin, an old drug, brings a new era to cancer therapy. Cancer J. 2015;21(2):70-4.

5. Soffer D, Shi J, Chung J, et al.Metformin and breast and gynecological cancer risk among women with diabetesBMJ Open Diabetes Research and Care 2015;3:e000049. doi: 10.1136/bmjdrc-2014-000049

There is no known medication or therapeutic technique that is able to completely prevent malignancies, oral or otherwise. Anyone who claims that metformin completely prevents Breast cancer is either a misinformed medical lay person, or a quack practitioner.

Still large number studies with longer FU is needed

Still under trials 😔

@ Amirali Moodi Ghalibaf

Yes. Please have a look at these useful RG links.

Article Metformin inhibits the development, and promotes the resensi...

Article Metformin, an Old Drug, Brings a New Era to Cancer Therapy

Article Recent Advances in the Use of Metformin: Can Treating Diabet...

Article Metformin in neoadjuvant systemic therapy of breast cancer p...

Article Metformin in cancer prevention and therapy

Thanks!

Hello, Metformin may prevent multidrug-resistant breast cancer.

See link below for more info.

Good luck!

https://www.google.am/amp/s/www.medicalnewstoday.com/articles/amp/320278

Cancer is often regarded as being the result of many steps in pathophysiology

Treatment may also be incremental and additive, rather than one magic bullet

I think there is a role in prevention and/or treatment of breast cancer for Metformin

Breast cancer is a common, terrible disease

We need to put all our strategies on the table to deal with it

Regards