The mechanism of the liquid-liquid phase separation phenomenon (LLPS), which is recognized as a fundamental principle of the organization of living cells, is currently being intensively studied "from above". Due to the complexity of the structure of biological molecules, this type of research is unlikely to reveal the mechanism, except for the functions that LLPS performs in the cell. We study the LLPS mechanism "from below" based on the fundamental properties of water and organic molecules: quantum, thermal fluctuations, nuclear quantum effect, hydrophobic interaction, statistical thermodynamics. We come to the conclusion that LLPS in water, in water-hydrocarbon, water-surfactant, water-polymer, water-biomolecular condensate systems are genetically related by changes in intermolecular interactions of water molecules. This was not paid attention to before and all the listed LLPS were studied separately in the absence of a unified approach to similar phenomena. However, surfactant micelle formation and LLPS are two sides of the same coin. A similar hypothesis, apparently, should be applied to the mechanism of formation of biomolecular condensates. To speed up research in this important scientific direction, I ask representatives studying such phenomena to write their opinions.

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