Has anyone measured the 15N/14N isotopic distributions in hiv virus and hiv cells relative to normal cells and other viruses? I am interested in such measurements. My interest follows an idea that I have on March 25, 2024 as, I , Reginald B. Little (RBL), reasoned that 15N in lysine and isotopes of Zn may be a new treatment for hiv. The heavy isotopes (66Zn, 68Zn and 70Zn) by RBL's theory have induced negative nuclear magnetic moments (NMMs) and 67Zn has permanent negative NMM relative to zero NMM of 64Zn. 64Zn is enriched in hiv and hiv enriched cells during infection. RBL thinks the 64Zn and its zero NMM more strongly binds 14N. But the negative NMM in 15N will causes stronger binding to heavier Zn isotopes due to their induced negative NMM and -NMM of 67Zn. The 15N in urea treatment can have more 15N in lysine and the interaction of 15N enriched lysine with 66Zn, 67Zn and 68Zn and 70Zn by negative NMMs interaction with negative NMMs for stronger binding for limiting replication of hiv virus. Urine is known to have certain inhibitor molecules, and I think such is due to 15N in these urines. Lysine is known to accelerate hiv replication. Thereby this isotopic enriched treatment will interact in new ways with these molecules of lysine and urine which are already known to affect hiv , but the 15N will alter their effects for anti-hiv outcomes. - Reginald B. Little (March 26, 2025)
Based on prior research Little, Snowton and Uziel, 15N is crucial for proper functioning of telomeres { Cancer cells possess different isotopic enrichment: Isotopic induced functionalizations of normal DNA mutations leading to cancer - ScienceDirect }. It is known that hiv develops into AIDS and cancer is one ailment from AIDS. As my theory of cancer developing by depletion of 15N and enrichment of 13C in normal cells to transform the normal cells to cancer cells, the 15N depletion in hiv infection would support cells becoming cancerous. Is there any evidence of AIDS patients having depleted 13C isotope? Within last few data I noticed that researchers deterimine that hiv virus disrupts DNA and alter telomeres so they go into senescence. See { The Complex Interactions Between HIV-1 and Human Host Cell Genome: From Molecular Mechanisms to Clinical Practice }. Such hiv altering telomeres and perhaps telomerase for senescence has to involve depleting 15N. This supports my reasoning that 15N in lysine and ingesting 67Zn, 66Zn, 68Zn and 7oZn may be effective treatment for hiv. - Reginald B. Little
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