In meta-analysis of binary outcomes, what should we do when the occurrence of outcome is zero in both groups?

In conducting meta-analysis of binary outcomes (in RCTs), in case the risk ratio has not been reported, what should we do with the studies that the number of outcomes occurrence is zero in both...

09 January 2021 2,802 5 View

How to calculate ratio of means and ratio of geometric means?

In conducting a meta-analysis, sometimes, some studies have reported geometric mean, while others have reported arithmetic mean. One solution for pooling these studies is calculating the ratio of...

11 December 2020 4,663 3 View

Is (Are) there any valid corpus containing geographical events queries?

Hi all, I'm currently looking for a question corpus to have a plausible number of spatial events queries. I found MS MARCO dataset in which I could extract a reasonable number of geographical...

08 December 2020 7,844 2 View

Do I have to assume sphericity or not when conducting two way repeated measures ANOVA in graphpad prism 8?

I am analyzing data obtained from a crossover study conducted on same animals evaluating the effect of two different anesthetic drugs on heart rate, respiratory rate, pulse oximetry, rectal...

28 September 2020 6,408 4 View

What are the general antibody concentrations in flow cytometry?

Hi everybody, I am trying to block Fc receptor by human IgG for a specific experiment (it's not flow cytometry), in an adherent cell, not a suspension. I know my primary antibody working...

20 September 2020 9,119 5 View

How to interpret arima model with regressors in r?

Hi there; I need to produce such an equation for a time series using arima model: y(t) = y(t-1) + a*x(t) + b*x(t-1) I know if I use for example arima (1,0,0) with x as the exogenous...

07 August 2020 7,438 6 View

Why some use seasonal ARIMA(p,d,q) (P,D, Q) instead of SARIMA?

Hello everyone. I am trying to use ARIMA model for a time series with seasonality. As I am new to this topic, I use the internet as my guide. My question is why anyone should use Seasonal ARIMA...

05 August 2020 219 4 View

How can I add stations to HBV-Light model?

Hi everyone. I've been using the original HBV model, so far. I might need to change it to HBV-light. Does anybody know how to add stations to HBV-light software? I can see there is this...

01 April 2020 1,032 7 View

How to define the parameters of Spatio-Temporal variogram models?

Hi everyone; I have a question regarding the parameters of variogram modelling. Does anyone know how to choose parameters such as Sill, Range and ... for the time, space and joint components of a...

10 February 2020 2,381 6 View

How to change tunit in VariogramST (R)?

Hi there, I am trying to use VariogramST function in R, for spatial-temporal kriging. The values I am working on, are monthly based; while in the function VariogramST, the predefined "tunit" is...

27 January 2020 5,986 3 View

Looking for Materials with high thermal expansion coefficient and high temperature resistance?

03 March 2021 8,272 1 View

Is there any test to determine the cardiovascular risk of patients with obesity? from the perspective of obesity?

We found tests to determine cardiovascular risk taking into account lipid profile, blood pressure, age, history of diabetes, other laboratories. But when weight is involved, there is a paradox. I...

02 March 2021 6,036 1 View

How can we calculate the sample size for rodents for a particular period of time?

How can we calculate the sample size for rodents for a study for one year? Are there any specific protocols to be followed for designing rodent sampling? How long should be the sampling interval...

01 March 2021 1,056 3 View

Would fecal samples stored at -20C for over a year impact metagenomic analysis?

Dear All, I have access to some rodent fecal samples that have been stored at -20C instead of -80C. Anyone have experience with the impact of stowage condition on comparative metagenomic analysis...

01 March 2021 2,512 1 View

How to grow E.coli on the low salt LB agar plate with 50 or 100ug/ml of Blasticidin?

Hello, I would like to ask how to grow E.coli which resists 50 or 100ug/ml of Blasticidin. I have tried many methods by using low salt Luria-Bertain(LB) agar plate. However, no colonies grow. Let...

01 March 2021 2,027 2 View

Why do my MCFs not form monolayer?

Hello, I am looking for some expertise on culturing MCF7s. I purchased them from ATCC and I have been following all media and culture conditions. Media is EMEM with 10% FBS and 10ug/mL of...

27 February 2021 3,904 2 View

What are the pros and cons for mice versus rats?

Hi Everyone, I am designing a pilot study using rodents to assess the effects of simulated space environments (radiation + altered gravity) on microbiome and immune system. I have limited...

24 February 2021 1,825 3 View

Are there lab markers/pens resistant to Roti-Histol?

Hi, I'm looking for a pen/marker to write on the smooth, transparent (non-frosted) part of microscopy slides which does not get washed away by alcohols and most importantly Roti-Histol. I want to...

24 February 2021 9,902 5 View

Can the problems of overfitting be solved without cross validation?

For an overfit data set the cross validation error will be much bigger than the training error. Is it true or false?

23 February 2021 3,616 2 View

How to manage western blot for proteomics data validation?

Hi Everyone, I am a bigginer in western blotting and I am trying to use it for validation of my proteomics data. I have: two regulated proteins with molecular mass of 40 and 73 kDa one control...

23 February 2021 6,671 4 View