The most common way to induce T2DM is to feed them a high fat diet, otherwise you can use genetic models such as Ob/Ob ans db/db. Some strains are more resistance to DIO (diet induced obesity), and some will become obese but won't necessarily become diabetic.

STZ injection is one of the widely used methods to induce DM.

Abbas Latif depending on which type you want to induce 1 or 2 you have your answers

Marie Mortreux dr. Marie Mortreux: it is type 2.

Abbas Latif for type 2, my recommendation about HFD is the most used. STZ will destroy the islets.

I thank you Marie Mortreux, but I am not a physician I am a physist. what is HFD ?

high fat diet. You have different types, high sucrose, high fat, both... diet induced obesity is what you are looking for