Dear colleagues, as part of an underway systematic review into the efficacy of nicotine replacement therapy on levels of agitation among psychiatric inpatients, for completeness, co-authors and I are looking for recommendations of papers related to this topic. Any suggestions would be sincerely appreciated. Please see PROSPERO registration for further details; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=158871
Nicotine reacts with many of the psychoactive drugs used in treating psychosis.
See chart on slide 47.
Some the agitation effects of psychopharmaceutical interventions may be up-regulated or down-regulated by cigarette smoke leading to the concept of self-medication.
I would suggest this article by Hassanzadah et al. (2019) as potentially helpful. Although, especially in schizophrenia, nicotine may be helpful as "self-medication" for negative symptoms, other work suggests that chronic nicotine use may lead to increased anxiety and increased catecholamine levels with tachycardia and hypertension. This paper references most of the leading authors in the field. Best,
Steve Mann
Dear Jacob D King,
I think these articles would help:
1-Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function
DOI: 10.1016/j.bcp.2009.05.021.
2-Nicotine and caffeine modulate haloperidol-induced changes in postsynaptic density transcripts expression: Translational insights in psychosis therapy and treatment resistance
DOI: 10.1016/j.euroneuro.2018.01.006.
3- Nicotine enhances antisaccade performance in schizophrenia patients and healthy controls
DOI: 10.1017/S1461145713000011.
4-Nicotine for schizophrenia
url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105838503&site=ehost-live
5-Antipsychotic property of a muscarinic receptor agonist in animal models for schizophrenia
DOI :10.1016/j.pbb.2008.06.023.
6-An analysis of the rewarding and aversive associative properties of nicotine in the neonatal quinpirole model: Effects on glial cell line-derived neurotrophic factor (GDNF)
DOI : 10.1016/j.schres.2017.03.024.
7-Nicotine and clozapine selectively reverse a PCP-induced deficit of PPI in BALB/cByJ but not NMRI mice: comparison with risperidone
DOI :10.1016/j.bbr.2005.08.023.
8-Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: a preliminary study
url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105243422&site=ehost-live
9-Effects of nicotine nasal spray on cognitive function in schizophrenia
DOI: 10.1038/sj.npp.1300881.
10-Different outcomes after acute and chronic treatment with nicotine in pre-pulse inhibition in Lister hooded rats
DOI: 10.1016/s0014-2999(00)00658-0.
11-Functional alterations of nicotinic neurotransmission in dopamine transporter knock-out mice
DOI : 10.1016/j.neuropharm.2007.02.002
**I am not completely sure if these papers are exactly what you are looking for, but I hope you find helpful.
Need anything else - [email protected]
Regards
Nicotine stimulates the release of the chemical dopamine in the brain. Dopamine is involved in triggering positive feelings. It is often found to be low in people with depression, who may then use cigarettes as a way of temporarily increasing their dopamine supply. However, smoking encourages the brain to switch off its own mechanism for making dopamine so in the long term the supply decreases, which in turn prompts people to smoke more.
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