Hi everyone, 

I have a question regarding penetrance of disease by mutation in a gene. 

I started my work on ALS disease. Data is reported with respect to penetrance of different genes in ALS in human. But when i read articles, mostly they didn't mentioned that how much penetrance they have observed in animal (mice, rat) groups. Its rarely mentioned and even then they show that not all animals show the disease phenotype rather than mentioning its penetrance. I have found some articles but it just related to SOD1 G93A mice model, that show severe phenotype within 16-20 weeks and most of the animals show the disease phenotype, but in human its penetrance is less than 15%.

I still don't have idea that, it may not be necessary to show the penetrance of a disease in mice/rat groups. And the penetrance in human should be similar to mice groups? I think its not necessary, right?

Thanks 

Best Regards

shabbir