There is a basic conflict between ‘drug’ and DMF and DMSO. Neither of these unpleasant solvents should be used on manmalian tissue.

Alan F Rawle thank you sir for reply..but sir is it any possibility to entrap this drug by using these solvents

Even if it worked you'd not be able to use any generated material for in vivo use. Better to look for appropriate surfactant + water or PBS.

Hi, any one working on PLGA 85:15 ????i want to know its release studies because its showing 18 hour but in maxi articles it has 20-30 days .kindly help me out from this issue Alan F Rawle

Validate the Dissolution method, if you are using the same method and medium as in maxi articles, also relook into the Analytical method.

Thanks,