Just as influenza has the NS1 protein to block the interferon system Is it known if a protein causes the same thing in the case of COVID19?

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Muhammad Yousuf

There does not appear to be any such interaction between SARS-CoV-2 and host ACE-2 receptor to block the interferon system. In fact reverse is true.

To see why, have a look at the links:

1. Preprint SARS-CoV-2 sensitive to type I interferon pretreatment.

2. Article SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in...

3. Article The antiviral effect of interferon-beta against SARS-Coronav...

Isam Alkhalifawi

Mechanisms of Severe Acute Respiratory Syndrome Pathogenesis and Innate Immunomodulation

Matthew Frieman and Ralph Baric

Alireza Tabibzadeh

Dear Manuel, based on another emergent Coronaviruses it has been suggested that the ORF3 and ORF8 of the SARS-CoV-2 are important in innate immunity response and interferon response.