Aspirin is the old drug but still new research is revealing new uses. Can it be better using aspirin in nanoparticles?
yes, it is possible to produce aspirin nanoparticles. you can do it by emulsion techniques, milling or laser fragmentation. Please consider that solubility is an issue, since solubilty of aspirin in water is high, nanoparticlles would dissolve if not stabilized/protected.
With laser fragmentation, we have fabricated organic nanoparticles in water and vitamin c and capsaicin nanoparticles in ethanol, see:
Wagener, P. ; BARCIKOWSKI, S.: Laser Fragmentation of Organic Microparticles into Colloidal Nanoparticles in a Free Liquid Jet. In: Applied Physics A 101 (2010), Nr. 2, S. 435–439
and
Schnoor, A. ; Petersen, S. ; BARCIKOWSKI, S.: Laserfragmentierung von anorganischen und organischen Mikropartikel-Suspensionen zu Nanopartikel-Kolloiden. In: Chemie Ingenieur Technik 82 (2010), Nr. 3, S. 317–326
I am working on aspirin nanoparticles using ionic gelation as my Ph.D work but the problem i am facing is solubility for
that i am dissolving the aspirin in methanol or ethanol and then i am working with the drug. can any one tell me about the problem that can created or encountered by my method of doing work. And i have searched the net i have not found any aspirin related nanoparticle related work pls tell me is it good continue the work with aspirin.
I remember an article where aspirin nanoparticles were embedded in a polymer (perhaps use chemical mname instead of trade name of the drug). I am sure that you will find it in the WoS.
No, acetylsalicylic acid. Acetylation of salicylic acid was my first ever organic synthesis ;-)
So what can we expect to happen for aspirin because we are using along with water i am expecting it may leads to
hydrolysis of acetyl salicylic acid.
Stephan Barcikowski
Acidum acetylsalicylicum is slightly soluble in water, is not so high, 1g/100-1000ml
it's very easy one, try to use some hybrid network -like PEG, PVP, PVA and mixed with asperin, and finally synthesis/adsorb with the nanoparticles surface.
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