nanoparticles from crystalline drugs may be fabricated by laser fragmentation. Just take a microparticle (or crystallone powder) suspension and irradiate it with short (preferrably ultrashort) laser pulses.
Video at the example of laser-fragmentation of gold:
http://youtu.be/4n1AoN2YNzo
Paper on laser-fragmentation of drugs:
J. P. Sylvestre, M.-C. Tang, A. Furtos, G. Leclair, M. Meunier and J.-C. Leroux, J. Control. Release, doi:10.1016/j.jconrel.2010.10.034