I'm interested in metals unbalance in some neurodegenerative disorders such as ataxia. Usually metals are suggested to have a key role in the oxidative stress observed in many diseases. In which way vanadium could increase the oxidative stress in cells or mythocondria compartments?
Is there any knowledge about it?
Dear Stefania,
Maybe the following papers will help you:
Afeseh Ngwa H, Kanthasamy A, Anantharam V, Song C, Witte T, Houk R, Kanthasamy AG. Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease. Toxicol Appl Pharmacol 2009;240(2):273-85. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753722/pdf/nihms-140990.pdf
Aschner M, Levin ED, Suñol C, Olopade JO, Helmcke KJ, Avila DS, Sledge D, Ali RH, Upchurch L, Donerly S, Linney E, Forsby A, Ponnuru P, Connor JR. Gene-environment interactions: neurodegeneration in non-mammals and mammals. Neurotoxicology 2010;31(5):582-8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912949/pdf/nihms-196865.pdf
https://www.researchgate.net/publication/285738434_Vanadium_and_neurotoxicity_A_review
Ngwa HA, Kanthasamy A, Jin H, Anantharam V, Kanthasamy AG. Vanadium exposure induces olfactory dysfunction in an animal model of metal neurotoxicity. Neurotoxicology 2014;43:73-81. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062607/pdf/nihms567668.pdf
Ngwa HA, Ay M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Neurotoxicity of Vanadium. Adv Neurobiol 2017;18:287-301. https://link.springer.com/chapter/10.1007/978-3-319-60189-2_14
Folarin OR, Snyder AM, Peters DG, Olopade F, Connor JR, Olopade JO. Brain Metal Distribution and Neuro-Inflammatory Profiles after Chronic Vanadium Administration and Withdrawal in Mice. Front Neuroanat 2017;11:58. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524677/pdf/fnana-11-00058.pdf
Folarin OR, Adaramoye OA, Akanni OO, Olopade JO. Changes in the brain antioxidant profile after chronic vanadium administration in mice. Metab Brain Dis. 2017 Jul 25. doi: 10.1007/s11011-017-0070-9. [Epub ahead of print]. https://www.researchgate.net/publication/318683780_Changes_in_the_brain_antioxidant_profile_after_chronic_vanadium_administration_in_mice
Best wishes from Germany,
Martin
Article Vanadium and neurotoxicity: A review
Article Changes in the brain antioxidant profile after chronic vanad...
Out of my scope, so I can not post a scientific comment.
Regards, Emad
may be useful
https://www.scribd.com/document/321409754/Progress-in-Neurodegeneration-The-Role-of-Metals
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