It is claimed by many that calorie restriction and exercise can reverse Type 2 Diabetes Mellitus. What is the opinion of experts such as diabetologists and scientists ? Is there any scientific data to support this ?
Dear Vishwas, the following papers may help you: Hallberg SJ, Gershuni VM, Hazbun TL, Athinarayanan SJ. Reversing Type 2 Diabetes: A Narrative Review of the Evidence. Nutrients. 2019;11(4):766. https://www.mdpi.com/2072-6643/11/4/766
Lemieux I. Reversing Type 2 Diabetes: The Time for Lifestyle Medicine Has Come! Nutrients. 2020;12(7):1974. https://www.mdpi.com/2072-6643/12/7/1974
Magkos F, Hjorth MF, Astrup A. Diet and exercise in the prevention and treatment of type 2 diabetes mellitus. Nat Rev Endocrinol. 2020;16(10):545-555. https://www.nature.com/articles/s41574-020-0381-5
Shakoor H, Apostolopoulos V, Feehan J, Ali HI, Ismail LC, Al Dhaheri ASOS, Stojanovska L. Effect of Calorie Restriction and Exercise on Type 2 Diabetes. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2021;42(1):109-126. https://www.sciendo.com/article/10.2478/prilozi-2021-0010
Best wishes from Germany, Martin
Respected Martin Sir,
Thank you for your reply. According to this paper, reversal of type 2 diabetes mellitus is indeed possible. However, adherence to low calorie and low carbohydrate diet is sometimes difficult. Also genetic vulnerability should also be considered.
Thank you for this interesting question. I believe the answer is yes, and no, depending on the individual afflicted.
In a young and otherwise relatively healthy person with a nascent diagnosis, and with a willingness to permanently adopt lifestyle changes, including addressing sleep disorders, I believe the answer is unequivocally yes: their type II DM is truly reversible. In someone with a chronic diagnosis who has denied opportunity for lifestyle changes and who may have persistent untreated sleep apnea, the answer is almost certainly no.
Gestational diabetes provides an interesting model for the reversibility of glucose dysregulation.
I share these thoughts and opinions not as an expert in type II DM per se, but as a physiologist and clinician familiar with diabetes as a metabolic and medical problem. Thanks again for this great question!
I am not expert in this field but want to add that, if the subject age is under 45 and can give 3-4 hour of exercise per day including aerobic and resistance. It will be really helpful, it will be approximately reversed but can come back after subject gain weight or pauses the training.
Calories: generally for a male 1800cal is required, so for Diabetes, subject has to completely exhaust the intake calories. A good training program can be designed based on the lifestyle of subject.
In short, exercise and right nutrition can make it possible.
According to recent research, type 2 diabetes cannot be cured, but individuals can have glucose levels that return to non-diabetes range, (complete remission) or pre-diabetes glucose level (partial remission) The primary means by which people with type 2 diabetes achieve remission is by losing significant amounts of ...
https://www.joslin.org › patient-care
Can Type 2 Diabetes Be Reversed?
Dear Vishwas Chavan . Yes it is possible for some people to reverse it. The diet changes and weight loss, may be able to reach and hold normal blood sugar level. See the links: https://www.webmd.com/diabetes/can-you-reverse-type-2-diabetes#:~:text=Although%20there's%20no%20cure%20for,mean%20you're%20completely%20cured.
https://www.joslin.org/patient-care/diabetes-education/diabetes-learning-center/can-type-2-diabetes-be-reversed
https://diabetesstrong.com/is-type-2-diabetes-reversible/
https://www.diabetes.org.uk/diabetes-the-basics/type-2-reverse
Kindly see also the following useful RG links: Article Reversal of type 2 diabetes: Normalisation of beta cell func...
https://www.dovepress.com/a-review-of-current-trends-with-type-2-diabetes-epidemiology-aetiology-peer-reviewed-fulltext-article-DMSO
https://diabetesjournals.org/care/article/39/11/2080/37234/Type-2-Diabetes-The-Pathologic-Basis-of-Reversible
Article Reversibility of diabetes mellitus: Narrative review of the evidence
Article Reversing Type 2 Diabetes: A Narrative Review of the Evidence
Aref Wazwaz Good References Sir. But I wonder whether calorie restriction may lead to severe hypoglycemia, which is more dangerous than hyperglycemia.
Vishwas Chavan . Yes calorie reduction is very important to certain limit by using intermittent fasting as an example. See the following useful RG links:
https://www.nature.com/articles/emm201452
Article Understanding hypoglycemia in hospitalized patients
Article Effects of calorie restriction and weight loss on glucose an...
Article Effects of Calorie Restriction on Health Span and Insulin Re...
I have been following this issue for some time. Attended seminar, went through some proposed projects. Calorie restriction and exercise are believed to remove the barrier (fat) between the incoming ligand (insulin) and insulin receptors. In general, removal of fat enables insulin to gain access to its receptor on the skeletal muscle which in turn increases storage, metabolism of glucose,... I have even saw a person who claimed to be free after regular follow up of intermittent fasting. My reservation is PCOS, where both lean and fat patients encounter type II diabetes mellitus. In these individuals, scientists are investigating pathways other than insulin pathway to explain the why. The pathways include, TGF, ToR,...
Still in PCOS, there are evidences of increased insulin sensitivity with exercise. @Barbora De Courten
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