I'm not talking about paradigm shifts like quantum computing, but rather just a new CPU architecture that isn't based on the x86 or other existing systems, or at least not one of the commonly used systems.
For reference, here's my current design idea, which is pretty bizarre, I think. https://medium.com/technology-past-present-and-future/design-idea-the-1802%C2%B2-afb85607cf0a