Hi Ernesto,

Check this article (link below) and ask around you for a skilled programmer. They should be able to figure out a way to compute the Tmax pretty easily.

Good luck!

http://www.ncbi.nlm.nih.gov/pubmed/23538410

Hi Mr Ernesto, 

Getting a reliable/valid measurement after post-processing of perfusion (CT perfusion and Perfusion weighted MRI) is always a challenge. Hence choice of a validated software is essential.

We use MIStar (Apollo Medical Imaging , http://www.apollomit.com/products.htm) obtained as part of research agreement for INternational Stroke Perfusion Imaging REgistry (INSPIRE) study. We are getting reproducible measurements with the software for both CTP and PW_MRI. It is being used widely for acute ischemic stroke with many validated studies. However it does not give Tmax but Delay time (DT) which is similar to TMAX. 

In past I have used Olea Medical Imaging software and PGUI. PGUI is still available under a research agreement if you contact the Researchers. PGUI Perfusion Analysis Software; Center of Functionally Integrative Neuroscience, Aarhus University Hospital Norrebrogade, Denmark.

Another free software is Perfusion Mismatch Analyzer (PMA). I have not used it but is free to download and ready to use. (http://asist.umin.jp/data-e.shtml) 

Hope you find this information useful.

Thanks

Thank you Xavier and Mahesh for your invaluable remarks, they will help me prepare my paper for resubmission. Best regards,

Ernesto

Dear Vincent, thank you for the fantastic review/advice about DSC-MRI post processing !!, I will certainly review all the links you have sent to me. My best  wishes for 2015 !!

Thank you Peter, I will check it out the software and company, regards, Ernesto.

Thank you Peter, I will check the link.

Imaging Biometrics LLC also offers several proven perfusion-MRI analysis tools such as IB NeuroTM.

Thank you Kathleen for your comment.