Does anybody know if the two isoforms of the glucocorticoid receptor are differentially expressed (either mRNA or protein) in limbic system structures such as the hippocampus or the amygdala? Most of the information that I can find the compares GRalpha and GRbeta expression in the immune system.
Here you find a thesis that sheds light on your question:
http://ubt.opus.hbz-nrw.de/volltexte/2011/720/pdf/document1.pdf
We have the three publications that you need.
Lei Cao-Lei, Songkiet Suwansirikul, Prapan Jutavijittum, Sophie B Mériaux, Jonathan D Turner, Claude P Muller (2013) Glucocorticoid receptor gene expression and promoter CpG modifications throughout the human brain Journal of Psychiatric Research 47: 11. 1597-607.
Simone R Alt, Jonathan D Turner, Melanie D Klok, Onno C Meijer, Egbert A J F Lakke, Roel H Derijk, Claude P Muller (2010) Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed. Psychoneuroendocrinology 35: 4. 544-556 May.
Melanie D Klok, Simone R Alt, Alicia J M Irurzun Lafitte, Jonathan D Turner, Egbert A J F Lakke, Inge Huitinga, Claude P Muller, Frans G Zitman, E Ronald de Kloet, Roel H DeRijk (2011) Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder Journal of Psychiatric Research 45: 7. 871-8 July.
Hope these help..... actually the link from Béatrice above is to Simone Alt's thesis who is an author on two of the three papers (an one of my past PhD students).
Jon
Thanks, Jon. This information is very helpful. I had come across a paper similar to these from Seckl (I believe) but had not found these 3.
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