I am making Poly Glycerol Sebacate nanoparticles by solvent evaporation and nanoprecipitation, but material got hydrolyzed upon adding water. I want to replace aqueous phase. Which chemical should be used instead of water?
Dear Ramish Riaz, yes it very common way of nanoparticles préparation, just make Google search with the following keyword : 'nanoparticles preparation in non aqueous media'. Or to use solvent displacement technique instead (link below). Please feel free to tell me if you need a specific documents. My Regards
https://pubs.rsc.org/en/content/articlelanding/2017/py/c6py02192a#!divAbstract
Dear Ramish Riaz, yes it very common way of nanoparticles préparation, just make Google search with the following keyword : 'nanoparticles preparation in non aqueous media'. Or to use solvent displacement technique instead (link below). Please feel free to tell me if you need a specific documents. My Regards
https://pubs.rsc.org/en/content/articlelanding/2017/py/c6py02192a#!divAbstract
I think this article will help you. A review article focused on growing number of RAFT PISA developed for non-aqueous media. "Polymerization-induced self-assembly of block copolymer nanoparticles via RAFT non-aqueous dispersion polymerization".
Abdelkader BOUAZIZ I am using same technique for preparation, but FTIR results show breakage of ester bond. I have attached my FTIR of polymer and the particles by SD method. I have tried all surfactants, even without surfactants. My drug is inert. Even have tried to replace water with Phosphate Buffer to balance pH. But issue is there.
In this paper they had not performed FTIR. I have tried to mail them but did not got response.
Kindly help me in this regard? If there is any other technique or paper?
Dear Ramish Riaz, I think there is no ester bond breakage. In the second paper I think they attribute similar behavior to the transesterification. The first paper FTIR is done but I don't have access to check and compare. Good Luck
https://pubmed.ncbi.nlm.nih.gov/31811769/#:~:text=Abstract,and%20treatment%20of%20diabetic%20retinopathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940955/
Abdelkader BOUAZIZ Then why there the peak at 1735 is transferred to 1631?? Can it be attributed to cross linking?
I have read this article also, These two are the only article available on PGS nanoparticles.....they have made PGS/Gelatin particle but their particle retained 1735 ester peak in nanoparticles.
I am have tried this also but gelatin i not appropriate for my use. I need elastic properties.
This is very common shifts in IR spectroscopy. I am suspecting transesterification, but it may also be induced by secondary interactions. If it is really important for your work you have to dig profound in literature. Also I will check for other references, you will be informer by that immediately. My Regards
Abdelkader BOUAZIZ Thanksss alottttt, It will be big big help, I am stuck in my PhD just because of this FTIR result and thinking to start again from zero with some new material.
Actually i am of medical background with little knowledge in Chemistry. It will be of great help if you recommend me some good articles for FTIR also. I am reviewing lot of literature but i was thinking this peak to be of precursor sebacic acid not due to further crosslinking.
Dear Ramish Riaz, you are lucky, please check this nice free RG document, they noticed such shifts and explained. Take this as a support to justify your findings and continue your work. Wish you all the best.
https://www.researchgate.net/publication/255769802_Microwave-assisted_Rapid_Synthesis_of_Polyglycerol-sebacate_Elastomers
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