Micro- RNAs encoded by the virus are called vmiRNAs. The precursor of the vmiRNA is called pre-CvmiR-5 and the mature vmiRNA is called CvmiR-5-5p.
It has confirmed that the sequence of CvmiR-5-5p is specific to and conserved among SARS-CoV-2.
One study identified 55 miRNAs that were altered in COVID-19 patients during early-stage disease, compared to healthy controls. The most strongly upregulated miRNA was miR-31-5p, which is associated with inflammatory disorders. The study also found a three-miRNA signature (miR-423-5p, miR-23a-3p and miR-195-5p) that could independently classify COVID-19 cases with high accuracy .
Another study suggested that SARS-CoV-2, the virus that causes COVID-19, may act as a “miRNA sponge” and disrupt the normal function of host miRNAs. The study found that some miRNAs, such as hsa-miR-302c-5p and hsa-miR-16-5p, may be targeted by the virus and affect the expression of genes related to the ACE2 receptor, the entry point of the virus into human cells .
These studies indicate that miRNAs may be involved in the molecular mechanism and clinical outcome of COVID-19, and may have potential applications as biomarkers or therapeutic targets. However, more research is needed to validate and elucidate the role of miRNAs in COVID-19.
If you want to learn more about miRNA related with COVID-19, you can check out these web search results:
- Altered microRNA expression in COVID-19 patients enables identification of SARS-CoV-2 infection
- SARS-COV-2 as potential microRNA sponge in COVID-19 patients
- MicroRNA May Explain Individual Differences in COVID-19 Severity
- Altered microRNA expression in COVID-19 patients enables identification of SARS-CoV-2 infection - PLOS
- Evaluation of Plasma Proteome and miRNA Changes Related to COVID-19 Severity
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