I know that many people rely on cLogP and logD predictions. Another parameter I've heard about is the "Topological Polar Surface Area" (TPSA) which is said to correlate with passive molecular transport through membranes. I think there are lots of tools in the web that make such predictions. One free software that gives you cLogP values is the ACD/ChemSketch Freeware. I hope this helps. Ciao!