Antihistamines block the actions of histamine and also have effects on inflammation which is independent of histamine-H(1)-receptor antagonism. Many physicians prescribe antihistamines for asthma patients. However, recent studies have shown that controlling allergic rhinitis with antihistamines has a small, indirect effect in improving asthma symptoms.
No, antihistamines do not improve bronhial asthma. Some benefits could be present in rhinitis, asociated to asthma.
Antihistamine therapy can be added in the presence of allergic rhinitis in asthma.
Not quite. At first glance the concept looks sensible, but it doesn't work. So far, the best way to control asthma is with inhaled corticosteroids (ICS), either alone or in combination with beta-agonists (short-acting, SABA, or long-acting, LABA). Newer drugs are biologics that counteract Th2-type inflammation, such as omalizumab or mepolizumab.,
Thank you very much for your replies. In addition to corticosteroids, I have noticed drastic improvements after using magnesium supplements in asthma patients. Since allopathic preparations causes GIT problems, magnesium phosphoricum 6x homeo salt b.i.d worked very well to avoid acute phase. It is known that Magnesium can relax smooth muscle and hence cause bronchodilation by competing with calcium at calcium-mediated smooth muscle ̶ binding sites.
Yes, due to their effects at the histamine receptor, antihistamines, in a dose-dependent fashion, inhibit the release of preformed mediators such as histamine and mediators synthesized including the metabolities of arachidonic acid from mast cells and basophils. Antihistamines also show, in a concentration-dependent manner, anti-inflammatory and immunomodulatory activity through their effects on epithelial cells, endothelial cells, macrophages, eosinophils, and T lymphocytes.But they are considered as controller not rescue medication