Among the ARBs antihypertensives drugs Olmesartan has been reported to cause villous atrophy and chronic diarrhea a condition called sprue-like enteropathy , is there any experiences with the other ARBs such as Losartan, Candesartan,...?
To my knowledge there have been no report of causing this gastrointestinal effect other ARCs than Olmesartan to this moment
Hello Erwa!
In the literature, a significant association between the use of ARB and diarrhea was found. Up to now, there are no studies that explored the mechanisms that may be involved in causing diarrhea by this class of drugs. The Micromedex health-care series report that 2-3% of patients treated with losartan, irbesartan, and valsartan had diarrhea. No diarrhea was reported with the use of candesartan, telmisartan, eprosartan, and olmesartan. In anotther study, the prevalence of diarrhea in elderly patients who were taking ARB was 12.2% and the individual drugs implicated were losartan, irbesartan, valsartarn, candesartan, and telmisartan.
Micromedex Healthcare Series Report. Available at: http://www.thomsonhc.com.
Pilloto et al.The Prevalence of Diarrhea and Its Association With Drug Use in Elderly Outpatients: A Multicenter Study. Am J Gastroenterol. 2008;103(11):2816-2823.
Please take a look at the following link and PDF attachment.
https://www.ajmc.com/journals/supplement/2005/2005-11-vol11-n13suppl/nov05-2224ps392-s394
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