Is there any role for allopurinol in primary prevention of cardiovascular diseases like aspirin?

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Victor C. Kok

Hi, Ugur, we have done a population-based matched-cohort study to test if allopurinol use is associated with beneficial cardiovascular outcomes, the answer is no.

Article Allopurinol Therapy in Gout Patients Does Not Associate with...

Ali Movahed

Allopurinol and aspirin are both competitive inhibitors of enzymes. Allopurinol inhibits Xanthine oxidase and may control the production of active oxygen species, so it can prevent oxidative stress and may help in prevention of injuries to heart tissues during open heart surgery, or Ischemic heart diseases. You can go through my work done on Allopurinol: Ali Movahed , KG Nair,TF Ashavaid, Pavan Kumar, Free radical generation and the roleof allopurinol as a cardioprotective agent during coronary artery bypass grafting surgery. Can J Cardiol vol 12 FEBRURY 1996.

Reynold Agustinus

Just check this new published article in BMJ

Heart. 2015 Jan 5. pii: heartjnl-2014-306670. doi: 10.1136/heartjnl-2014-306670.

Allopurinol use and risk of non-fatal acute myocardial infarction.

de Abajo FJ, Gil MJ, Rodríguez A, García-Poza P, Álvarez A, Bryant V, García-Rodríguez LA.

hope it would be useful