I have a proteomics dataset and would like to target some proteins from the dataset with some inhibitors. Is there any repository which provides a list of proteins and small inhibitory molecules?
I do know of a general database like this but here is one for kinases:
Kinase Inhibitor Database - http://www.kinase-screen.mrc.ac.uk/kinase-inhibitors
Also try here - http://www.biodbs.info/Di.html
And some companies have pathway inhibitors lists
Yoram
its a drugbak.ca where u can find all testing and approved drug list along with there target name especially proteins
www.drugbank.ca/
ChEMBL is one of the biggest repositories for small molecules-ligand information. Check it at https://www.ebi.ac.uk/chembl/.
NetPro™: NetPro™ is a comprehensive database of Protein-Protein and Protein-Small molecules interaction, consisting of more than 320,000 interactions captured from more than 1500 abstracts, approximately 1600 published journals and more than 60,000 references.
The strength of NetPro™ lies in the complete manual curation of literature. It covers several entities other than proteins as interacting partners, like RNA, DNA, processes, etc. with well defined, exhaustive interaction terms.
NetPro™ has received several accolades for the quality and quantity of data it contains. It has become an important resource for target identification, validation and pathway research and has subscribers from all over the globe including 3 of the top 5 pharmas.
Highlights:
- Highly Granular Data content
- Standard terms and exhaustive controlled vocabulary, mostly sourced from public domain
- 20 species covered & 9 major classes of interactions (including both direct and indirect types)
- Kinetic parameters, pharmacokinetics/pharmacodynamics values, dose response details etc
- Hierarchical display of experimental location to sub cellular level and detection methods (90 unique detection methods)
- Functional classification of proteins in Gene Ontology terms
- A'molecule-entity-universe', a relational network of proteins and small molecules that enables relating different molecules
- pfam IDs for domains
- Regulatory (proteins/mutations/conditions/processes) and quantitative differences in interactions that facilitates comparative studies
- Correlation of interaction to disease and also expression, mutation of genes in disease
- Quarterly updates on interactions
Contact: [email protected]
URL: www.molecularconnections.com
Dear Priyanka,
Links of databases of proteins ligands are available at MetaComBio website (Protein ligands tab):
http://www.uwm.edu.pl/metachemibio/index.php/about-metacombio.
Another opportunity for access to multiple databases is OMICTools website:
http://omictools.com/
With best regards
Piotr Minkiewicz
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