There might be relationship. It was found that some glucosyl/glucuronosyl transferases in the feeding females were upregulated in mountain pine beetle. Glutathion S Transferases are important detoxifying enzymes found in fat tissues. An NADPH-dependent nitroreductase has been reported in the soluble fraction of adult female house flies that changes parathion to aminoparathion. Nitrobenzene reductase activity has also been found in fat bodies of cockroaches. Also there are tons of literature on this thing. Before answering, I would like to know to which particular group of insecticide and which particular group of insect (atleast order) you are talking about. I would suggest reading Robert et al. 2013 Plos One.
Thank you sir for the response. I am working on Hemipteran group, Helopeltis theivora exposed to quinalphos and deltamethrin.. please recommend some other papers. Somehow while assessing the general esterase, GST and CYP450 enzyme activity in female and male of Helopeltis, I found male are showing less activity than female.