I would like to define a reference range for urine albumin/creatinine (ACR) value to verify that I successfully set diabetic nephropathy (DN) model in sprague dawley rats. For this purpose, I reviewed some articles but I got confused with the results...Of course, multiple factors including the dose of streptozocin (STZ), time period of since the injection of STZ, age of rats could affect the ACR values, but the ACR values are changing in a wide range in the articles I reviewed.
For example, Nagaish et al (2017) defined the rats (treated with 55 mg/kg STZ) with 93.82+/- 20.45 mg/gr ACR as having diabetic nephropathy. Mestry et al (2016) measured urine albumin as 0.40 gr/ 24 hour and urine creatinine as 12.53 mg/ 24 hour, in this regard ACR value for those rats (with DN) is corresponding to 32000 mg/g (if my math does not mislead me) and Lee et all (2010) noted that 7.08 ug/mg ACR (6 weeks after treatmen of 65 mg/kg STZ ) and 17.23 ug/mg ACR (12 weeks after the treatment). Therefore, I would be very grateful if you clarify that wide range of ACR values. Furthermore, what is the normal range of ACR values for normal (healty) rats anyway. Thank you in advance....
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