I am planning to compare the adverse effect profile of Vilazodone, the newer SSRI with Fluoxetine.
SSRIs were reevaluated - adverse events were also addressed. The coding schemes are named.
http://www.bmj.com/content/351/bmj.h4320
SMARTS checklist
Glasgow Antipscyhotic Side-effect Scale (GASS)
The ANNSERS
SMARTS
Global Assessment Scale
These are the some of the scales used to assess the ADRs in psychiatry. As per my understanding there is no special scales for SSRI .
Hello Anil Kumar [Mysore Nagaraj,
1. I searched Pub Med database search engine using keywords "Vilazodone and Fluoxetine" ....I found 11 articles with 2 being Full FREE Texts that may help you.
Here is a chart of ADR's during clinical trials and the article it came from:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278186/table/t1-ptj3701028/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278186/
2. I did find the following article and its abstract:
Curr Med Chem. 2012;19(12):1846-63.
Selective serotonin reuptake inhibitors (SSRIs): therapeutic drug monitoring and pharmacological interactions.
Mandrioli R1, Mercolini L, Saracino MA, Raggi MA.
Abstract
New-generation antidepressants are a heterogeneous class of drugs used in the treatment of depression and related disorders. This review deals with the first new-generation antidepressant class to enter the pharmaceutical market, i.e., selective serotonin reuptake inhibitors (SSRIs), which are still the most prescribed and widely used ones. Their common characteristics are the comparable clinical efficacy, good tolerability and relative safety in comparison to "first generation antidepressants", i.e. classic tricyclic antidepressants and monoamine oxidase inhibitors. This class of drugs includes fluoxetine, citalopram, paroxetine, sertraline, fluvoxamine and, since 2011, vilazodone. In this review, the main pharmacodynamic and pharmacokinetic properties of the six commercially available SSRIs are described, focusing on side and toxic effects, chemical-clinical correlations, interactions with other drugs, the role of therapeutic drug monitoring (TDM) and related bioanalytical methodologies. PMID: 22414078 [PubMed - indexed for MEDLINE]" http://www.ncbi.nlm.nih.gov/pubmed/22414078
Please note, while is considered a serotonin (5-HT) reuptake inhibitor (SSRI), it is also a 5-HT-1A receptor partial agonist, it is included with the comparison as an SSRI in the above article, according to the abstract it is the 6th SSRI on the list.
https://pubchem.ncbi.nlm.nih.gov/compound/VilazodoneRespectfully,
i did not find a side by side comparison chart of the two and do not have full access to the comparison article above.
I too am not aware of a specific "rating scale" for SSRI's....
I hope this helps,
Respectfullym
Jeanetta Mastron
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