The bottom line question is : can the use of statins reduce mortality in HIV patients on HAART? It was proposed that the pleomorphic effects of this drug class could act reverting the state of chronic dysregulated inflammation seen in HIV infection. In case of beneficial effects, does this effect exist regardless of cholesterol levels, like the data of JUPITER trial?
Yes, there is a trial looking at the effects of statin use in HIV patients. It is an ACTG trial but I'm not sure what the trial number is. You may want to look at some of the work done by Grace McComsey from University Hospitals, Cleveland, OH.
Sure, the first author may be Chris Longerenecker. Also working on the statin HIV work is Nick Funderburg from Michael Lederman's lab at Case Western Reserve University.
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