It's an hypothetical doubt. A metal complex containing two dppz (intercalative ligands present in transposition ) one of the ligands can produce intercalation with DNA base pair. What about the another one? Can it produce intercalate with another DNA base pair or the same DNA base pair again at different positions (Because DNA is lengthy molecule it may bend )?Kindly let me know the details.
Cisplatin causes intrastrand as well as interstrand linkages and cause bends in DNA. In the same vein, I would assume that it is possible to form intrastrand linkages as well as interstrand linkages with your compound. I am curious as to how big your molecule is and if its dimensions exceed the width of the DNA molecule.
http://www.medscape.com/viewarticle/563882_4
Depending upon the nature of metal complex containing two dppz, intercalation with with another DNA base pair is possible.
There are some papers describing the DNA binding properties of Ru(dppz)2 complexes. They typically intercalate one of the ligands, while the other is exposed to the solvent. Both dppz can't intercalate simultaneously. Take a look at:
V. Pierroz, T. Joshi, A. Leonidova, C. Mari, J. Schur, I. Ott, L. Spiccia, S. Ferrari and G. Gasser, J. Am. Chem. Soc., 2012, 134, 20376–20387.
T. Joshi, V. Pierroz, C. Mari, L. Gemperle, S. Ferrari and G. Gasser, Angew. Chem. Int. Ed., 2014, 53, 2960–296.
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