It seems that water controls the biological response to biomaterials surface by mediating protein adsorption. A full appreciation of role of water may lead to elucidate the basic mechanisms underlying biocompatibility.
You could check into protein substrate interaction research. If you really want to get the details I suggest looking at the results achieved with sum-frequency-generation spectroscopy. Start easy, with water molecules at interfaces vs. organic solvents escalate to salts and peptides. Together with the knowledge on Protein folding in liquids of different molarities you get your picture. Hope that helps ;) good luck and have fun
Thank you very much for your valuable suggestions, I'll try this method.
There are a few experts on the North American continent. If you wish you could check in with Prof. Patrick Kölsch in Seattle. Good for the boundary problems between physics and biology ;) . That is of course a personal opinion. Best wishes to you
water controls energetics of protein adsorption is not completely explained or studied. Studies done by spectroscopy especially frequency spectroscope can be useful.
With ethylene glycol-like surfaces, it has been proposed that the surface structure mimics or enhances disorder in the arrangement of water molecules at the interface, leading to repulsion of the biomolecule by such surfaces. You may have seen classic papers on this: Wang, R. L. C.; Kreuzer, H. J.; Grunze, M.
Journal of Physical Chemistry B (1997), 101 (47), 9767-9773 ; Feldman, K.; Haehner, G.; Spencer, N. D.; Harder, P.; Grunze, M.
Journal of the American Chemical Society (1999), 121 (43), 10134-10141 ; but there is this that I just spotted: Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold: protein adsorption, platelet adhesion, and surface forces
Tomohiro Hayashi , Yusaku Tanaka , Yuki Koide , Masaru Tanaka and Masahiko Hara
Phys. Chem. Chem. Phys., 2012,14, 10196-10206
DOI: 10.1039/C2CP41236E
Someone correct me, but I think in essence this is covered by the field of hydrophobic interactions.
Water displacement from the interface always occurs concomitantly with protein deposition to produce the required "conditioning film" controlling subsequent events of bioadhesion..Measuring water contact angles is not enough to determine binding strength, just binding rate.. Sticking fast does not equal sticking hard (or long)..Related biomaterials mistakes are described at http://www.bestthinking.com/article/permalink/1682?tab=article&title=bionanotechnology-and-other-biomaterials-mistakes
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