The TLR2 polymorphisms, including an insertion/deletion (Ins/Del) polymorphism in exon 1 and a synonymous polymorphism in exon 3 (rs3804100), have been associated with protection against aggressive periodontitis in a Japanese population (Takahashi and others 2011). In contrast, another study failed to find any statistically significant associations between the carriage of the TLR2 SNPs and generalized aggressive periodontitis (E