Is there any correlation between cytosolic cAMP levels and neuronal firing properties ?
yes - I believe this is how metabatropic receptors coupled to Gs modulate neuronal activity. I think changes in neuronal activity related to long-term synaptic potentiation have been linked to increased cAMP and subsequent phosphorylation of AMPA receptors by PKA, which modulates AMPA receptor localization and function. This should get you started Article Global and local missions of cAMP signaling in neural plasti...
cAMP sensitive covariation of I(A) and I (H) voltage dependence tunes rebound firing in dopaminergic neurons. The level of express of ion channel has been demonstrated to vary over a threefold to four fold range from neuron to neuron. Cell to cell covariability of voltage dependence is sensitive to cAMP. Covarying of I(A) and I (H) voltage dependence increases the dynamic range of rebound firing while covarying their amplitudes has a homeostatic effects on ebound firing.
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