Hi I have searched a lot about finding a polymer or any material or peptide to have good cell adhesion properties and also have thermal resistance properties that could be sterilized in autoclave. I haven't got answer yet. Maybe I missed something in my search. I found in one article that RGD peptide could resist 120 C temperature without losing its cell adhesion properties (RGD Surface Functionalization of the Hydrophilic Acrylic Intraocular Lens Material to Control Posterior Capsular Opacification). I hope someone have experience in this issue
Polypropylene can normally be autoclaved. RGD peptides still work after autoclaving even if their normal conformation changes a bit. Here is an article detailing surface functionalization of polypropylene with protein. Therefore, this method ought to work for peptides.
Dear Chris,
Sorry that I do not have the answer but I am now struggling with the same question ...
But I found another article saying that RGD grafted PDMS can resist harsh cleaning and sterilization like UV or autoclave (RGD PEPTIDE CONJUGATION PROMOTES CELL ADHESION ON PDMS)
Have you find anything elseon the subject untill now ?
Thanks !
Phuong-Anh Dang
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