Hi
Usually, immunization in mice induces via intramuscular , subcutaneous , intraperitoneal , and intranasal routes.Is there an association between the type of adjuvant and the route of vaccine administration?
Dear Abdol satar Pagheh
production of killed vaccines are need adjuvants which administered only by intramuscular and subcutaneous routes, and may cause extensive inflammation and other side effects on the injection site and therefore should be considered.
best regards
Side effects upon using adjuvants are dangerous sometimes due to local inflammation and increased fever...some times they cause hypersensitivity or even anaphylaxis, hence route of injection used in immunization has high link with adjuvant type used.. regards
An association in what sense? Some classical adjuvants, such as alum, are only able to be administered through subcutaneous and intramuscular routes, for example, they cannot be used for mucosal vaccination. Others, as previously mentioned, may cause extensive inflammation and other side effects on the injection site and therefore alternatives should be considered.
Dear Abdol satar Pagheh
production of killed vaccines are need adjuvants which administered only by intramuscular and subcutaneous routes, and may cause extensive inflammation and other side effects on the injection site and therefore should be considered.
best regards