I know Cetuximab does not recognsize mouse EGFR and there is a publication demonstrating that 7A7 does not bind human or mouse EGFR (10.18632/oncotarget.24242).
What other options are there in case no monoclonal antibodies are available?
I had problems working with Iressa in vivo, is this working well for you?
Thanks a lot
Dear Adrià Cañellas Socias,
You may want to look at the info below:
https://www.thermofisher.com/antibody/primary/target/egfr?ef_id=Cj0KCQiA-K2MBhC-ARIsAMtLKRuKzFyRG5Gl17wlu8dVPTAKiJO3If4fiDiFMwWUAj34vAXl1pyvHHQaAjsmEALw_wcB:G:s&s_kwcid=AL!3652!3!214721626720!b!!g!!%2Bmouse%20%2Banti%20%2Begfr&cid=bid_pca_aup_r01_co_cp1359_pjt0000_bid00000_0se_gaw_nt_pur_con&gclid=Cj0KCQiA-K2MBhC-ARIsAMtLKRuKzFyRG5Gl17wlu8dVPTAKiJO3If4fiDiFMwWUAj34vAXl1pyvHHQaAjsmEALw_wcB
https://www.rndsystems.com/products/mouse-egfr-antibody_af1280
https://www.creativebiolabs.net/Anti-Egfr-Recombinant-Antibody-clone-7A7-24352.htm
Dear Len,
Thanks a lot fro your reply. I did not detail my question enough, I am looking for an EGFR blocking antibody for in vivo experiments.
Thank you!
OK, here is some additional info:
How does anti EGFR therapy work?
Its main pharmacological mechanism is to inhibit the phosphorylation of EGFR tyrosine kinase caused by the ligands binding and then block a series of reactions such as gene transcription and cell proliferation induced by the activation of the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) ...
https://academic.oup.com/gastro/article/8/3/179/5861161
https://www.nature.com/articles/onc2013245
https://cancerres.aacrjournals.org/content/61/13/5090
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