The main cell *lineage* of interest for MS is the oligodendroglia. Oligodendrocytes are lost in MS, and endogenous oligodendrocyte precursors (OPCs) are presumed to generate new oligodendrocytes.

There are oligodendroglial cell lines, but whether these are reliable models for the behaviour of oligodendrocytes and/or oligodendrocyte precursor cells is debatable.

Are you studying the disease, the endogenous remyelination process or cell therapies?

I don't think anyone can guarantee you that all subtypes of MS share the same mechanisms. Asking for a cell line predictive in all circumstances is probably too optimistic, but it depends on what your question is...

Dear Stuart Iain Jenkins 

Thanks for your answer. Really, I want to work on MS but the limitation is very higher than our equipment in this field. We don't access the brain samples of MS patients. Also, we don't have any specific cell lines and the development of EAE model is very time  and cost consuming. I decided to work on macrophages of MS patients, which we can sort them from PBMCs of whole blood. I think that whereas the source of inflammatory cytokines are the blood cells, we can use them and work on their activation process. what is your opinion?

Dear Stuart Iain Jenkins 

I want to work on cell therapy for MS, can you tell me about cell line model for this experiment?

Hi Khatereh,

What experiment are you trying to perform? 'Cell therapy' does not make clear what you want to achieve.