Are you looking to have the sorbent qualities of a specific protein, set of proteins or proteins in general?

Given that individual proteins have very different sorbent properties dependent on function, your question is a bit vague.

I try to mimic the adsorption of pollutants to the "protein phase" of tissues in organisms. Hence, I would be interested in sorbent properties of proteins in general and an artificial substance with similar properties. A combination of diverse SPE materials might mimic some important molecular interactions as associated with protein based tissue. But I wonder if there is a single material that´ll do the job as well.

Ah... right, so in reality you are looking at how tissues sorbent qualities.

You need to carefully prepare your hypothesis and design your experiment to match.

Are you going to mimic skin? This will influence which pollutants pass through and at what rate

Are you going to mimic cell membranes? This will influence which pollutants pass through and at what rate, it will also adsorb and hold some pollutants

Are you going to mimic tissue? The cellular nature results in layering effect, so you will get differential rates of transfer

Are you aiming to mimic the heterogenous nature of tissues? Some tissues are bioaccummulative for certain pollutants.

I like to mimic internal exposure of water organisms. Kinetics do not have priority here, since I like to investigate internal exposure at equilibrium with the environment. Hence, water-protein or water-lipid partitioning coefficients are more important. I try to find a material, which will adsorb pollutants in concnetration ratios similar to protein rich, lean tissue, were fat is not the main receiving phase.

Have you considered using Matrigel?

Remember, that instead of sorbent as a whole material, you can use immobilisation to cover some commercial sorbent with specific type of molecules.

regards,

G

Thanks, that are both interesting approaches. I will read into this.