Dr. Ali:

You can follow the papers below for getting more insight into your query:

1. Association of helicobacter pylori infection and colon cancer.

Strofilas A, Lagoudianakis EE, Seretis C, Pappas A, Koronakis N, Keramidaris D, Koukoutsis I, Chrysikos I, Manouras I, Manouras A.

J Clin Med Res. 2012 Jun;4(3):172-6. doi: 10.4021/jocmr880w. Epub 2012 May 15.

PMID: 22719803 [PubMed] Free PMC Article

2. Helicobacter pylori but not gastrin is associated with the development of colonic neoplasms.

Selgrad M, Bornschein J, Kandulski A, Hille C, Weigt J, Roessner A, Wex T, Malfertheiner P.

Int J Cancer. 2014 Sep 1;135(5):1127-31. doi: 10.1002/ijc.28758. Epub 2014 Feb 11.

PMID: 24496701 [PubMed - indexed for MEDLINE]

Related citations

Select item 24164483

3. Helicobacter pylori infection is associated with advanced colorectal neoplasia.

Shmuely H, Melzer E, Braverman M, Domniz N, Yahav J.

Scand J Gastroenterol. 2014 Jan;49(1):35-42. doi: 10.3109/00365521.2013.848468. Epub 2013 Oct 28.

PMID: 24164483 [PubMed - indexed for MEDLINE]

However still a direct link has not been concretely established.

Wang F et al reported in their meta-analysis (Wang F, Sun MY, Shi SL, Lv ZS.Helicobacter pylori infection and normal colorectal mucosa-adenomatous polyp-adenocarcinoma sequence: a meta-analysis of 27 case-control studies.Colorectal Dis. 2014 Apr;16(4):246-52) that CagA-positive strains are associated with an increased risk of colon carcinoma, with and OR=1.22, however, due to the wide confidence interval (1.08-1.37, P = 0.05), this OR value is too close to non-significativity. Therefore, at the best of current knowledge, it does not seem that CagA could be an important risk factor for colon carcinogenesis. Nevertheless, in the cited study, the risk of carcinoma was not associated with H. pylori infection (P = 0.66), regardless of its virulence.