The diversities in biology, culture, lifestyle, environment, and socioeconomic status impact differences between males and females in predisposition, development, and clinical presentation. Genetic effects and epigenetic mechanisms, nutritional factors and sedentary lifestyle affect risk and complications differently in both sexes. Furthermore, sex hormones have a great impact on energy metabolism, body composition, vascular function, and inflammatory responses. Thus, endocrine imbalances relate to unfavorable cardiometabolic traits, observable in women with androgen excess or men with hypogonadism.

Article Sex and Gender Differences in Risk, Pathophysiology and Comp...

Yes of course

thanks dear Maha ...

Definitely a relationship. Although in some cases they are indirect

These links are very useful https://www.diabetesselfmanagement.com/blog/sex-hormones-and-health/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175332/

https://www.diabetesselfmanagement.com/blog/sex-hormones-and-health/

dear doctor

yes

and link may help

Article Is There a Relationship Between Sex Hormones and Erectile Dy...

regards

I would like to answer (Yes)

Source: Published December 16, 2009 by David Spero, BSN, RN

Sex Hormones and Health

Over 50% of men with Type 2 diabetes have lower than normal testosterone (T) levels. Men with Type 1 also tend to have low T levels. Now research shows that women with diabetes often have low levels of estrogen (E), and that raising E protects against kidney and heart disease in this population.

This sex hormone/diabetes connection may be very deep. In our current column on sex and diabetes, my partner and I reported on how raising T levels can help with insulin resistance (IR), lower cholesterol, and improve glucose control.

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Then I found some research from Georgetown researchers Shannon Sullivan, MD, and Christine Maric, PhD. They report that, among people without diabetes, men have much more kidney disease than women. But in people with diabetes, women and men have a more similar rate of kidney disease.

J Urol. 2006 Dec;176(6 Pt 1):2584-8.

Is there a relationship between sex hormones and erectile dysfunction? Results from the Massachusetts Male Aging Study.

Kupelian V1, Shabsigh R, Travison TG, Page ST, Araujo AB, McKinlay JB.

Author information

Abstract

PURPOSE:

The prevalence of erectile dysfunction increases as men age. Simultaneously, age related changes occur in male endocrine functioning. We examined the association between erectile dysfunction and total testosterone, bioavailable testosterone, sex hormone-binding globulin and luteinizing hormone.

MATERIALS AND METHODS:

Data were obtained from the Massachusetts Male Aging Study, a population based cohort study of 1,709 men. Self-reported erectile dysfunction was dichotomized as moderate or severe vs none or mild. Odds ratios and 95% CI were used to assess the association between sex hormone levels and erectile dysfunction. Multiple logistic regression models were used to adjust for potential confounders including age, body mass index, partner availability, phosphodiesterase type 5 inhibitor use, depression, diabetes and heart disease.

RESULTS:

Using data from the most recent followup, analyses were conducted on 625 men with complete data. A moderate decrease in erectile dysfunction risk was observed with increasing total testosterone and bioavailable testosterone levels. However, this effect was not apparent after controlling for potential confounders. Increased luteinizing hormone levels (8 IU/l or greater) were associated with a higher risk of erectile dysfunction (adjusted OR 2.91, 95% CI 1.55-5.48) compared to luteinizing hormone levels less than 6 IU/l. A significant interaction between luteinizing hormone and total testosterone levels showed that increased testosterone levels were associated with a decrease in risk of erectile dysfunction among men with luteinizing hormone levels greater than 6 IU/l.

CONCLUSIONS:

In this large population based cohort of older men we found no association among total testosterone, bioavailable testosterone, sex hormone-binding globulin and erectile dysfunction. Testosterone levels were associated with a decrease in risk of erectile dysfunction only in men with increased luteinizing hormone levels.

PMID: 17085164 DOI: 10.1016/j.juro.2006.08.020

thanks for all to answer ...

I think yes

thanks dr.Ali

https://www.diabetesselfmanagement.com/blog/sex-hormones-and-health/

The answer of Dr. Asaad Ali Karam is a scientific answer.

Greeting

Dr.Assad Ali Karam,

Thanks for your scientific explanations.

Best regards...

Yes surely sex hormones and its level in blood play a role to control diabetes and also protect kidney and heart from illness ,,, Best regards ,,,,,Jawad Ali

Diabetic women reach menopause earlier than non-diabetics, suggesting lower baseline E levels.” They also point out that in the rat version of Type 2, females have lower estrogen levels compared to females without diabetes.

The value of hormone replacement therapy (HRT) for women has been questioned recently. But HRT still seems to prevent heart disease in women with diabetes.

A large study at Kaiser (with over 22,400 women) showed a 16% reduction in heart attack risk for those taking hormones who had not had a recent heart attack — a 25% reduction if taking both progesterone and estrogen and a 12% reduction in women taking only estrogen.

Over 50% of men with Type 2 diabetes have lower than normal testosterone (T) levels. Men with Type 1 also tend to have low T levels. Now research shows that women with diabetes often have low levels of estrogen (E), and that raising E protects against kidney and heart disease in this population.

This sex hormone/diabetes connection may be very deep. In our current column on sex and diabetes, my partner and I reported on how raising T levels can help with insulin resistance (IR), lower cholesterol, and improve glucose control.

Women with diabetes tend to have too little estrogen and/or too much testosterone (a “low E:T ratio”). Sullivan and Maric say this lack of estrogen is associated with increased kidney disease and worse outcomes.

postmenopausal women with Type 2 improved their glucose control with hormone replacement. Supplementing low-E women with the hormone 17-β-estradiol reduced the incidence of diabetes and protected against diabetic kidney disease. This is similar to reports on testosterone for men.

Dear Colleagues, Good Day,

"Sex and Diabetes: What You Wanted to Know

.....

And, truth is, many doctors don't feel comfortable prodding patients for details on sexual function. It's why the newly diagnosed quickly learn about eye, nerve, kidney, and heart damage from uncontrolled diabetes, but hardly ever hear how diabetes affects sexual health. It is important for people to be open and honest with their doctors regarding all health concerns—even problems with sexual function. Problems with sexual performance and satisfaction can signal other health issues.

Many men with erectile dysfunction, for instance, later learn that they have diabetes. For people who already have diabetes, sexual problems can indicate nerve damage, blocked arteries, and even out-of-whack hormones. Though there's a lot yet to learn about sexual dysfunction in people with diabetes, researchers are certain of one thing: Chronic high blood glucose is behind many sexual problems people face, and the first line of action is to improve glucose control.

Honey, Not Tonight

Low libido, or sexual desire, is a real problem, one that affects people with diabetes more than those without. Men and women experience low libido as a result of poorly controlled diabetes. If your sex drive is stalled, first look to your diabetes control and take steps to lower your blood glucose levels. Then consider your medications. Certain drugs, such as antidepressants, can lower sexual desire, so talk to your doctor.

Researchers theorize that inflammation may also dampen desire. "Sexual desire is a brain-driven event," says Stacy Tessler Lindau, MD, MAPP, director of the Program in Integrative Sexual Medicine at the University of Chicago. "If inflammatory molecules cross the blood-brain barrier and circulate in the area where there is sexual desire, then it's plausible the desire for sex may be affected." Another possible culprit: low testosterone, which often affects men and women with diabetes."...

Please, see the reference for more details:

http://www.diabetesforecast.org/2012/nov/sex-and-diabetes-what-you-wanted-to-know.html?referrer=https://www.google.iq/

Thanks for answer

Yes there is indirect relationship

Sex hormones, obesity, fat distribution, type 2 diabetes and insulin resistance: epidemiological and clinical correlation

https://www.google.ae/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uact=8&ved=0ahUKEwidgpqD_7jYAhVDQBQKHWNLA5gQFghIMAU&url=http%3A%2F%2Filarjournal.oxfordjournals.org%2Fcontent%2F45%2F2%2F160.full&usg=AOvVaw2SW32fs0a7v-oV1vtlxqK2

thanks dear dr. Dharmesh ,dr.Mohamed and dr.Viji.....

There are many research confirm the relationship between the diabetes and sex hormones

thanks dear dr Ahmad

It intersection between pathways and signals, intertwined to trigger different reactions to people, the immune system and genetics

The diversities in biology, culture, lifestyle, environment, and socioeconomic status impact differences between males and females in predisposition, development, and clinical presentation. Genetic effects and epigenetic mechanisms, nutritional factors and sedentary lifestyle affect risk and complications differently in both sexes. Furthermore, sex hormones have a great impact on energy metabolism, body composition, vascular function, and inflammatory responses. Thus, endocrine imbalances relate to unfavorable cardiometabolic traits, observable in women with androgen excess or men with hypogonadism.

Article Sex and Gender Differences in Risk, Pathophysiology and Comp...