I'd like to build a graphical user interface that adapts according to eye pupil diameter, then I'd like to try to detect some human vision problems and to provide a graphical user interface according to the level of the problem of human vision.
Pamplona, Vitor F. and Oliveira, Manuel M. and Aliaga, Daniel and Raskar, Ramesh "Tailored displays to compensate for visual aberrations". ACM Transactions on Graphics. Volume 31 (2012), Proceedings of SIGGRAPH 2012., pp. 87:1-87:12.