Dear specialists in proteomics,

I was wondering if there exists a database of human-like proteins only, which is downloadable in FASTA form (i.e. like Ref Seq but also containing immunoglobulins)? I would like to use this to BLAST against to search for sequence similarity.

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How about these ones:

ftp://ftp.ensembl.org/pub/release-100/fasta/homo_sapiens/pep/

and

https://www.uniprot.org/uniprot/?query=%28taxonomy%3A9606%29+AND+reviewed%3Ayes

with instructions here:

https://www.uniprot.org/help/human_proteome

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I have looked at many—to name a few: from the BLAST website, the

• non-redundant (nr) database (too large and messy as it also contains other proteins like drug sequences, other species,...)
• SwissProt database (quite large but if you know a way to filter out only the curated part of the homo sapiens data, that would be great! I'd love to hear if someone has done this successfully.)
• ref seq database: Almost what I am looking for. This would be a good base to combine with a human immunoglobulin FASTA database. Does anyone know any?

I am new to the field and would be very thankful for any ideas and advice.

Thanks a lot! :)

Linnéa