the question in another way
can give me an example of any biomarker correlated with itself in level; when measuring from different sites in the body
like level of calcium in bone, serum, and CSF?
can this apply to all biomarkers like
CTLA4 in tissue by IHC
CTLA4 in flowcytometry
serumCTLA4
are the three-level from the same gene expression and have a linear correlation between them?
or anyone can reflect the level of others?
Hi Kaled Nather Taha . Calcium concentrations can be measured directly and give absolute concentrations as mmol/L. These concentrations can be compared and correlated.
Flowcy and IHC do not give absolute concentrations and therefore can't be compared and correlated.
convincing answer
I am grateful to you
thank you Steingrimur Stefansson
There definitely is, we have measured venous-arterial concentration differences over the ometum (visceral fat PMID: 17471294) or the kidney (ischemia reperfusion injury PMID: 19459788 ;PMID: 32781105) in order to measure biomarkers of inflammation (both conditions) or metabolism (ischemia reperfusion injury). We found clear signatures that are fully absent in peripheral blood (dilution and catabolism). Like with all projects, it is all about the question that you are interested in.
Bio markers for disease diagnosis such as type 2diabetes
LDL for blood pressure and P53gene and some Timor markers
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