Next-generation biofuels are toxic to microorganisms producing them, thus adversely affecting the production yield. The expression of efflux pumps presents a promising strategy for many biofuels like the longer chain alcohols, alkanes, alkenes and cyclic hydrocarbons, however recent studies show evidence that these are not effective at exporting short-chain alcohols. Could there be methods to make these efflux pumps less specific to solvents and still perform their function?