TERT is a gene coding the enzymatic component of telomerase. The second component TERC is massively overexpressed in cervical cancer tissue.
Hello Erik,
A wide number of genome studies suggest that TERT is a susceptibility gene for the development of many cancers. Essentially it promoter mutation is an early genetic event by activating telomerase. Deregulation of telomerase expression in somatic cells might involve in oncogenesis. Therefore, TERT inhibition has been proposed by many groups, as a target for cancer therapies, which is very popular as a telomerase-based anti-cancer strategy!
Hello
yes , The telomerase is activated in various stages of cervical cancer
Kindly look at these articles :
# Amplification of TERT and TERC genes in cervical intraepithelial neoplasia and cervical cancer
https://www.researchgate.net/publication/268987136_Amplification_of_TERT_and_TERC_genes_in_cervical_intraepithelial_neoplasia_and_cervical_cancer
# Environmental Factors Inducing Human Cancers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521879/
Good Luck
Article Amplification of TERT and TERC genes in cervical intraepithe...
Thank you for your answers. Do you have any data regarding mRNA and methylation of TERT and TERC genes ?
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