I'm trying to incorporate curcumin in my polymer scaffold.
1. Is idea of soaking the 'scaffolds' in the curcumin solution is good?
2. will there not be any wastage of curcumin while incorporation in 'hydrogel solution' during fabrication? what should be done to avoid the wastage during fabrication process of the scaffolds?
Curcumin is a physiologically active substance that is used in biochemistry as an antioxidant. If this substance is introduced into the structure of a three-dimensional polymer, then direct contact of this antioxidant with the external environment is excluded. Only slow diffusion can occur, that is, a long-acting antioxidant will be obtained. If we consider your task this way, then the pores of the framework should be larger than the curcumin molecules. But how do you put these large molecules in a framework? If exclusively by diffusion, then the time of diffusion filling of the frame will be quite comparable to the time of prolongation. The better you make such a composite, the longer it will have to be filled, which means it will be more expensive to produce.
Hi Pavithra,
The submerging method for the incorporation of biomolecules into 2D or 3D scaffolds which is also called "the dip-coating method" is a straightforward strategy, however, one of the inevitable but sometimes negligible problems about this procedure is free unencapsulated/unbound drug molecule residues in the feed solution. The efficiency of this approach is essentially correlated to your final objective.
Wish you the best of luck.
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